Robert S. Haltiwanger

The paper identifies new substrates of POFUT3 and POFUT4 using structural homology searches, showing MFAP2/MFAP5 are O-fucosylated and require POFUT3 for secretion.

This study shows that POGLUT1 is essential for muscle stem cell development and maintenance in mice, with loss of function leading to muscle defects and impaired repair.

This paper develops specific antibodies to detect O-fucose on nucleocytoplasmic proteins in protists, slime molds, and plants, revealing conservation of the O-fucome across species.

The paper analyzes O-fucose modification on NOTCH1 in POFUT1 S162L patient fibroblasts and finds reduced ligand binding and absence of O-fucose at EGF12.