Mark Larance

The paper identifies new substrates of POFUT3 and POFUT4 using structural homology searches, showing MFAP2/MFAP5 are O-fucosylated and require POFUT3 for secretion.

This study identifies a genetic locus affecting insulin sensitivity in mice, showing that Defa26 modulates glucose homeostasis through microbiome interactions.

This study identifies SEC61B as a regulator of calcium flux and platelet hyperreactivity in diabetes by linking ER stress to increased SEC61B expression and calcium leak.

This study develops pan-specific monoclonal antibodies to detect pseudaminic acids in bacteria, enabling deeper glycoproteomic analysis and improved phagocytosis of multidrug-resistant strains.

This study shows that VPS41 deletion causes insulin degradation and loss of beta-cell identity in mice, with lysosomal inhibition rescuing insulin content.

The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.

This study identifies 211 proteins associated with insulin secretory granules in MIN6 β-cells, including SCAMP3, which regulates insulin storage and secretion.

The paper develops a framework to construct multi-platform precision diagnostic pathways automatically, optimizing for accuracy and cost-effectiveness in clinical settings.

The paper investigates how RNA modifications m6A and 5hmC regulate gene expression in monocytes and macrophages during differentiation and polarization, finding their roles in transcript stability and function.

This study shows that SET-25 and SET-32 are needed for establishing but not maintaining transgenerational epigenetic silencing in C. elegans, indicating distinct genetic steps in the process.

This study identifies the Aquarius/EMB-4 helicase as essential for initiating small RNA-induced co-transcriptional gene silencing in C. elegans by facilitating HRDE-1 complex engagement with nascent transcripts.