Sensory experience and mTORC1 interplay orchestrates the maturation of cortical interneuron connectivity and tactile sensitivity
Clara A. Amegandjin, Maria Isabel Carreño-Muñoz, Ruggiero Francavilla, Jorelle Linda Damo Kamda, Marie Roussel, Antônia Sâmia Fernandes do Nascimento, Antoine Farley, Pegah Chehrazi, Alessandra G. Ciancone Chama, Bidisha Chattopadhyaya, Graziella Di Cristo
This study shows that mTORC1 dysregulation in PV interneurons affects tactile sensitivity and social behavior by altering connectivity and excitability.
bioRxiv · Jul 23, 2026 · PreprintNeuroscience