Graziella Di Cristo

This study shows that estradiol modulates cortical network states and auditory entrainment in mice and humans across the ovarian cycle.

This study describes a mouse model of DHDDS-CDG, showing seizures, myoclonus, and cognitive deficits linked to glycosylation defects and interneuron abnormalities.

This study shows that mTORC1 dysregulation in PV interneurons affects tactile sensitivity and social behavior by altering connectivity and excitability.

This study shows that sub-anesthetic ketamine reduces deviant detection responses in auditory cortex and posterior parietal cortex, affecting cellular, population, and mesoscale levels.

The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.

This study investigates how Syngap1 haploinsufficiency in GABAergic interneurons affects synaptic and intrinsic properties in mouse auditory cortex, linking these changes to auditory processing deficits in SYNGAP1-ID.

This study shows that p75NTR upregulation after perinatal hypoxia impairs PV GABAergic cell maturation and leads to cognitive deficits in adult mice, which can be reversed by p75NTR inhibition.

This study shows that reducing Hdac2 in PV+ cells enhances fear memory extinction in adults by downregulating Acan, a perineuronal net component.

This study shows that p75NTR in adolescent PV interneurons affects adult cognitive flexibility by altering PV cell connectivity and perineuronal net formation.

This study identifies sensory processing dysregulations in SYNGAP1 haploinsufficiency in mice and humans, suggesting they as potential translational biomarkers.

The paper shows that transient maternal IL-6 elevation during early neurodevelopment disrupts hippocampal connectivity and enhances glutamatergic synapses in offspring through the STAT3/RGS4 pathway.

This study shows that lysosomal storage diseases cause synaptic structure and neurotransmission defects before cognitive symptoms appear in mice and humans.

This study shows that p75NTR regulates PV cell connectivity maturation and promotes adult visual cortex plasticity by controlling synaptic timing and connectivity stability.