Selective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell proliferation
Rafael Rincón, Isabel F. Coira, Antoine Richieu, Fedaa Attana, Muriel Urwyler, Shozeb M Haider, Carole Bourquin, Philippe Bertrand, Muriel Cuendet
This study shows that inhibiting the ZnF-UBP domain of HDAC6 in multiple myeloma cells reduces proliferation and aggresome formation, suggesting it as a therapeutic target.
Cell Death Discovery · Apr 15, 2025Peer-reviewedCancer Biology