The magnitude of the secondary B cell response is primarily defined by antibody feedback inhibition rather than the number of memory B cells present
Malte Joe Hoormann, Noémi Becza, Lingling Yao, Anton V. Gorbachev, Stefanie Küerten, Magdalena Tary‐Lehmann, Greg A. Kirchenbaum, Paul V Lehmann
The study shows that the secondary B cell response magnitude is driven by antibody feedback inhibition, not the number of memory B cells before vaccination.
bioRxiv · Feb 23, 2026 · PreprintImmunology