Greg A. Kirchenbaum

This paper introduces a high-throughput method to assess the affinity distribution of antigen-specific B cells using an adapted ImmunoSpot assay, demonstrating its application in detecting affinity maturation after vaccination.

The study shows that the secondary B cell response magnitude is driven by antibody feedback inhibition, not the number of memory B cells before vaccination.

This study shows that delayed innate immune responses to influenza B virus in ferrets lead to weaker antibody responses compared to influenza A virus.