Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity
Regina Reimann, Martina Puzio, Antonella Rosati, Marc Emmenegger, Bernard Laurent Schneider, Pamela Valdés, Danzhi Huang A, Amedeo Caflisch, Adriano Aguzzi
This study identifies K27 as a critical residue for GDL toxicity and prion-related neurodegeneration using ex vivo reverse genetics in PrPC-deficient slices.
Brain Pathology · Nov 3, 2022Peer-reviewedNeuroscience