NeuroscienceBrain PathologyPeer-reviewed
Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity
Regina Reimann, Martina Puzio, Antonella Rosati…·Adriano Aguzzi
This study identifies K27 as a critical residue for GDL toxicity and prion-related neurodegeneration using ex vivo reverse genetics in PrPC-deficient slices.
4 citations