Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusion
Sachiko Kanaji, Alessandro Zarpellon, Roberto Aiolfi, Yosuke Morodomi, Jennifer Nagrampa Orje, Antonella Zampolli, Eric Won, Zaverio M. Ruggeri, Taisuke Kanaji
This paper demonstrates that human PAR1 expressed in mouse platelets affects hemostasis and arterial occlusion, with vorapaxar reversing these effects.
bioRxiv · Jun 3, 2025 · PreprintPhysiology