The RNA helicase DHX36/G4R1 modulates C9orf72 GGGGCC repeat-associated translation
Yi‐Ju Tseng, Siara N. Sandwith, Katelyn M. Green, Antonio E. Chambers, Amy Krans, Heather M. Raimer, Meredith E. Sharlow, Michael A. Reisinger, Adam E. Richardson, Eric D. Routh, Melissa A. Smaldino, Yuh‐Hwa Wang, James P. Vaughn, Peter K. Todd, Philip J. Smaldino
This study shows that DHX36 modulates RAN translation from G4C2 repeats, with depletion suppressing and overexpression enhancing translation.
Journal of Biological Chemistry · Jun 24, 2021Peer-reviewedMolecular Biology