Author

James P. Vaughn

NanoMedica (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Philip J. SmaldinoiD· 2 shared Yuh‐Hwa WangiD· 2 shared Aakrosh RataniD· 1 shared Adam E. RichardsoniD· 1 shared Amy Krans· 1 shared Anna R. Bartosik· 1 shared Antonio E. Chambers· 1 shared Eric D. RouthiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Philip J. SmaldinoORCID

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2 papers

Recent·Most cited

Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells

Anna R. Bartosik, Pei‐Chi Hou, Shangming Tang, James P. Vaughn, Philip J. Smaldino, Aakrosh Ratan, Marty W. Mayo, Yuh‐Hwa Wang

This study shows that loss of DHX36/G4R1 increases genome instability and innate immune gene expression in cancer cells, correlating with improved survival in B-cell acute lymphoblastic leukemia.

Nucleic Acids Research · Jun 14, 2025Peer-reviewedMolecular Biology

The RNA helicase DHX36/G4R1 modulates C9orf72 GGGGCC repeat-associated translation

Yi‐Ju Tseng, Siara N. Sandwith, Katelyn M. Green, Antonio E. Chambers, Amy Krans, Heather M. Raimer, Meredith E. Sharlow, Michael A. Reisinger, Adam E. Richardson, Eric D. Routh, Melissa A. Smaldino, Yuh‐Hwa Wang, James P. Vaughn, Peter K. Todd, Philip J. Smaldino

This study shows that DHX36 modulates RAN translation from G4C2 repeats, with depletion suppressing and overexpression enhancing translation.

Journal of Biological Chemistry · Jun 24, 2021Peer-reviewedMolecular Biology