Yuh‐Hwa Wang

NPC1 deficiency engages a lysosome - genome - immune program linked to neurodegeneration and cellular aging signatures

This study shows that NPC1 deficiency causes genomic instability and immune activation linked to neurodegeneration and aging, and identifies Fingolimod as a potential treatment.

Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells

This study shows that loss of DHX36/G4R1 increases genome instability and innate immune gene expression in cancer cells, correlating with improved survival in B-cell acute lymphoblastic leukemia.

Discovery of A Polymorphic Gene Fusion via Bottom-Up Chimeric RNA Prediction

The paper identifies 57 polymorphic chimeric RNAs, including SUZ12P1-CRLF3, and links one to Neurofibromatosis Type I through population-specific structural variants.

The RNA helicase DHX36/G4R1 modulates C9orf72 GGGGCC repeat-associated translation

This study shows that DHX36 modulates RAN translation from G4C2 repeats, with depletion suppressing and overexpression enhancing translation.

CNCC: An analysis tool to determine genome-wide DNA break end structure at single-nucleotide resolution

The paper introduces CNCC, a method to determine DNA break end structures at single-nucleotide resolution using high-precision genome-wide break mapping data.