USP7 couples DNA replication termination to mitotic entry.
Antonio Galarreta, Emilio Lecona, Pablo Valledor, Patricia Ubieto, Vanesa Lafarga, Julia Specks, Oscar Fernandez-Capetillo
This study shows that USP7 inhibition causes premature DNA replication termination and activates CDK1, leading to chromosome segregation defects and cell toxicity.
bioRxiv · Apr 20, 2018 · PreprintCell Biology