Species-Dependent Limitations of Murine Myocardium for Investigating the Combined Inotropic Effects of SERCA2a Stimulation and Myofilament Ca2+ Sensitization
Francesca Misitano, Natasha Giacomelli, Claudia Maniezzi, Marica Dente, Marina Scardigli, Corrado Poggesi, Josè Manuel Pioner, Gabriella Malfatto, Antonio Zaza, Cecilia Ferrantini, Francesco Lodola
The paper investigates the combined inotropic effects of SERCA2a stimulation and myofilament Ca2+ sensitization in murine myocardium, finding limited responsiveness to LEVO compared to human myocardium.
bioRxiv · Nov 2, 2026 · PreprintPhysiology