Author

Josè Manuel Pioner

University of FlorenceORCID 0000-0003-0179-3033Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Cecilia FerrantiniiD· 2 shared Corrado PoggesiiD· 2 shared Marica DenteiD· 2 shared Michael RegnieriD· 2 shared Sonette SteczinaiD· 2 shared Alberto MagiiD· 1 shared Antonio Zaza· 1 shared Ateeqa NaimiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPhysiology

Cecilia FerrantiniORCID

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3 papers

Recent·Most cited

PhysiologybioRxivPreprintNov 2, 2026

Species-Dependent Limitations of Murine Myocardium for Investigating the Combined Inotropic Effects of SERCA2a Stimulation and Myofilament Ca2+ Sensitization

Francesca Misitano, Natasha Giacomelli, Claudia Maniezzi…·Francesco Lodola

The paper investigates the combined inotropic effects of SERCA2a stimulation and myofilament Ca2+ sensitization in murine myocardium, finding limited responsiveness to LEVO compared to human myocardium.

DOI 10.64898/2026.10.30.762932

mouseexperimental assay

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PhysiologyCardiovascular ResearchPeer-reviewedJul 13, 2026

Long-term mavacamten exposure reduces force and sarcomere density in a hiPSC model of hypertrophic cardiomyopathy

Marianna Langione, Lucrezia Giammarino, Roberto Semeraro…·Josè Manuel Pioner

This study examines the long-term effects of mavacamten on sarcomere structure and function in hiPSC-derived cardiomyocytes from HCM patients, finding a biphasic reduction in force and structural remodeling.

DOI 10.1093/cvr/cvag159

humanbulk RNA-seq

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BiophysicsJournal of Molecular and Cellular CardiologyPeer-reviewedOct 28, 2025

Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.

Sonette Steczina, Saffie E. Mohran, Matthew Carter Childers…·Michael Regnier

This study investigates the R403Q mutation in beta-myosin heavy chain using porcine and human stem cell models, revealing altered contractile properties and mechanisms of hypercontractility and impaired relaxation.

7 citationstop 4%

humanmouse

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