Cytosolic interaction with RNA-helicase DDX39A titrates viral RNA G-quadruplex mediated α-Synuclein amyloidogenesis
Aanchal Jain, Shreya Tripathi, Cheshta Agarwal, Anubhab Biswas, Poojitha Sai Potharaju, Aratrika De, Shemin Mansuri, Arindam Mondal, Krishnan Harinivas Harshan, Swasti Raychaudhuri
The paper shows that DDX39A interaction with RNA reduces α-Synuclein amyloid formation, while viral rG4s enhance it, linking RNA dynamics to Parkinson's disease pathogenesis.
bioRxiv · Feb 25, 2026 · PreprintBiochemistry