Manganese availability determines insulin sensitivity by enhancing Akt activity
Jennifer R. Gamarra, Sei Higuchi, Timothy L. Yuan, YUKE XIE, Cong Liu, Niroshan Shanmugarajah, Hang Yang, Meredith O. Kelly, Sarah Anissa Hannou, Kathrin Schilling, Ana Navas‐Acién, Eunhee Choi, Anum Glasgow, Inna I. Astapova, Mark A. Herman, Rebecca A. Haeusler
This study identifies manganese as a regulator of Akt activity independent of PI3K, showing it enhances Akt catalytic efficiency and interacts with insulin to modulate glucose homeostasis.
bioRxiv · Sep 17, 2026 · PreprintPhysiology