Eunhee Choi

This study identifies manganese as a regulator of Akt activity independent of PI3K, showing it enhances Akt catalytic efficiency and interacts with insulin to modulate glucose homeostasis.

This study develops a de novo insulin receptor agonist, RF-409, which effectively treats severe insulin resistance in a mouse model by activating a mutant receptor and improving glucose homeostasis.

This paper designs synthetic insulin receptor agonists that modulate receptor conformation and signaling, showing improved potency and activity in disease mutants.