Mark A. Herman

This study identifies manganese as a regulator of Akt activity independent of PI3K, showing it enhances Akt catalytic efficiency and interacts with insulin to modulate glucose homeostasis.

This study identifies G3P-ChREBP as a mechanism linking Citrin Deficiency to metabolic dysfunction by activating FGF21 and lipogenesis, affecting food and alcohol choices.

This study uses snRNA-seq to analyze cold-induced changes in brown adipocyte subtypes in mice, identifying ChREBP's role in lipogenic adipocyte identity and plasticity.

This study integrates transcriptomic and metabolomic analyses to reveal novel regulatory functions of ChREBP in mitochondrial metabolism and cellular energy balance beyond its canonical roles in carbohydrate and lipid metabolism.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.