Lineage-specific CK2α deletion reshapes the transcriptome of hematopoietic stem cells toward an immune-primed state
Hannah Valensi, Rajesh Rajaiah, Marudhu Pandiyan Shanmugam, Daniyal Muhammad, Upendarrao Golla, Katherine Mercer, Anush Karampuri, Sinisa Dovat, Chandrika Gowda Behura, Yasin Uzun
This study shows that deleting CK2α in hematopoietic stem cells (HSCs) alters their transcriptome toward an immune-primed state, with tissue-specific effects on inflammatory and immune-related genes.
bioRxiv · Apr 15, 2026 · PreprintGenomics