Author

Marudhu Pandiyan Shanmugam

Pennsylvania State UniversityORCID 0000-0002-5217-2950Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Chandrika Gowda Behura· 3 shared Hannah ValensiiD· 3 shared Rajesh Rajaiah· 3 shared Upendarrao GollaiD· 3 shared Yasin UzuniD· 3 shared Katherine Mercer· 2 shared Muhammad DaniyaliD· 2 shared Sinisa DovatiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersGenomics

Chandrika Gowda Behura

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Lineage-specific CK2α deletion reshapes the transcriptome of hematopoietic stem cells toward an immune-primed state

Hannah Valensi, Rajesh Rajaiah, Marudhu Pandiyan Shanmugam, Daniyal Muhammad, Upendarrao Golla, Katherine Mercer, Anush Karampuri, Sinisa Dovat, Chandrika Gowda Behura, Yasin Uzun

This study shows that deleting CK2α in hematopoietic stem cells (HSCs) alters their transcriptome toward an immune-primed state, with tissue-specific effects on inflammatory and immune-related genes.

bioRxiv · Apr 15, 2026 · PreprintGenomics

CK2 inhibitor, CX-4945, enhances BH3 priming and promotes apoptosis of venetoclax-resistant AML by targeting antiapoptotic proteins

Muhammad Daniyal, Rajesh Rajaiah, Upendarrao Golla, Marudhu Pandiyan Shanmugam, Koby Duke, Katherine Mercer, Yasin Uzun, Hannah Valensi, Jeremy A. Hengst, Sinisa Dovat, Yi Qiu, Suming Huang, Chandrika Gowda Behura

bioRxiv · Dec 26, 2025 · PreprintPharmacology & Toxicology

CK2 inhibitor CX-4945 targets EWS-FLI1 signaling network and shows therapeutic efficacy in metastatic mouse models of Ewing Sarcoma

Muhammad Daniyal, Rajesh Rajaiah, Upendarrao Golla, Marudhu Pandiyan Shanmugam, Chloe Sholler, Jeremy Hengst, Abhinav Beeravally Nagulapally, Hannah Valensi, Lanza Matthew, Yasin Uzun, Giselle L. Saulnier Sholler, Chandrika Gowda Behura

This study shows that CK2 inhibitor CX-4945 targets EWS-FLI1 and reduces tumor growth and metastasis in Ewing Sarcoma models.

bioRxiv · Sep 24, 2025 · PreprintCancer Biology