Mechanical Stretch Kills Transformed Cancer Cells
Ajay Tijore, Mingxi Yao, Yu-Hsiu Wang, Yasaman Nematbakhsh, Anushya Hariharan, Chwee Teck Lim, Michael Sheetz
The paper shows that cyclic mechanical stretch induces apoptosis in transformed cancer cells but promotes growth in normal cells, with mechanoptosis driven by calcium influx and calpain activation.
bioRxiv · Dec 10, 2018 · PreprintCell Biology