Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA , a neurodegenerative disease in which the RIβ-L50R variant is expressed
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John Cornelis Van Swieten, Rodrigo A. Maillard, Friedrich W. Herberg, Ronit Ilouz
This study investigates the RIβ-L50R variant in NLPD-PKA, showing it causes misfolding, disrupts PKA holoenzyme assembly, and increases C-subunit nuclear translocation, with a potential therapeutic strategy to reduce dissociation.
FEBS Journal · Apr 17, 2025Peer-reviewedCell Biology