Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA , a neurodegenerative disease in which the RIβ-L50R variant is expressed
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa…·Ronit Ilouz
This study investigates the RIβ-L50R variant in NLPD-PKA, showing it causes misfolding, disrupts PKA holoenzyme assembly, and increases C-subunit nuclear translocation, with a potential therapeutic strategy to reduce dissociation.