Initiating mammalian reproduction from a single male genome
Shogo Matoba, Nonoko Umeda, M. Sakamoto, Sota Komatsubara, Pham Quoc Dinh, Asako Okamoto, Aoi Ito, Takumi Ando, Hirosuke Shiura, Kimiko Inoue, Atsuo Ogura, Toshiaki Hino, Takashi Ishiuchi
This paper demonstrates a method to induce male-to-female sex reversal in mice using Y-chromosome elimination and somatic cell nuclear transfer, enabling reproduction from a single male genome.
bioRxiv · Aug 4, 2026 · PreprintDevelopmental Biology