Takashi Ishiuchi

This paper demonstrates a method to induce male-to-female sex reversal in mice using Y-chromosome elimination and somatic cell nuclear transfer, enabling reproduction from a single male genome.

This study shows that Resf1 is essential for placental development and trophoblast cell-specific heterochromatin configuration in mice, with loss of Resf1 leading to retroelement upregulation and developmental defects.