Shogo Matoba

Initiating mammalian reproduction from a single male genome

This paper demonstrates a method to induce male-to-female sex reversal in mice using Y-chromosome elimination and somatic cell nuclear transfer, enabling reproduction from a single male genome.

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin

This study shows that Resf1 is essential for placental development and trophoblast cell-specific heterochromatin configuration in mice, with loss of Resf1 leading to retroelement upregulation and developmental defects.

Obox4 promotes zygotic genome activation upon loss of Dux

The paper identifies Obox4 as a redundant transcription factor that promotes zygotic genome activation in mouse embryos, compensating for the loss of Dux.

A non-mosaic humanized mouse model of Down syndrome, trisomy of the long arm of human chromosome 21 in mouse chromosome background

This paper describes a new non-mosaic humanized mouse model of Down syndrome with a nearly complete copy of the long arm of human chromosome 21.