Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice
Menglei Yang, Hafiz Muhammad Jafar Hussain, Manan Khan, Muhammad Zubair, Jianteng Zhou, Ao Ma, Xiongheng Huang, Jingwei Ye, Min Chen, Aoran Zhi, Tao Liu, Ranjha Khan, Asim Ali, Wasim Shah, Aurang Zeb, , Baolu Shi
This study identifies DNAH12 mutations causing male infertility by disrupting DNAH1 and DNALI1 recruitment in sperm flagella, confirmed in human and mouse models.
eLife · Mar 27, 2025Peer-reviewedGenetics