Ao Ma

A Chromatin-Structure-Guided Framework for Predictive and Interpretable Regulatory Genomics

CHROME improves regulatory genomics predictions by integrating physically validated chromatin interactions into graph models, enhancing accuracy and interpretability for ChIP-seq, eQTL, and variant pathogenicity.

Disentangling polymer confinement from specific-folding interactions reveals the drivers of E. coli chromosome organization

The paper develops a polymer simulation framework to distinguish specific-folding interactions from polymer compaction in E. coli, revealing SFIs shape chromosome organization and gene expression.

Effects of Lamina-Chromatin Attachment on Super Long-Range Chromatin Interactions

This study uses 3D polymer models to show that LAD-lamin interactions influence chromatin organization and induce super long-range chromatin contacts in mouse cells.

Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

This study identifies DNAH12 mutations causing male infertility by disrupting DNAH1 and DNALI1 recruitment in sperm flagella, confirmed in human and mouse models.