Author

Ranjha Khan

University of California, San FranciscoORCID 0000-0002-1010-4407Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Julie Deane SabaiD· 2 shared Adam Majcher· 1 shared Ao MaiD· 1 shared Aoran Zhi· 1 shared Asim AliiD· 1 shared Audrey K. IzuharaiD· 1 shared Aurang ZebiD· 1 shared Babak Oskouian· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Julie Deane SabaORCID

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3 papers

Recent·Most cited

Pyridoxine supplementation confers protection against SGPL1R222Q variant sphingosine phosphate lyase insufficiency syndrome

Ranjha Khan, María L. Allende, Ehtesham Khalid, Joanna Y Lee, E.W. Stone, Max Rodnick-Smith, Audrey K. Izuhara, Vadym Buncha, Georgina Gyarmati, János Peti‐Peterdi, Ranya Al-Khaledy, Jeffrey B. Hodgin, Gizachew Tassew, Babak Oskouian, Rachel Zhang, , Julie Deane Saba

The paper shows pyridoxine supplementation improves SPLIS symptoms in a patient and mouse model by reducing S1P levels and enhancing SPL activity.

bioRxiv · May 14, 2026 · PreprintMolecular Biology

Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

Menglei Yang, Hafiz Muhammad Jafar Hussain, Manan Khan, Muhammad Zubair, Jianteng Zhou, Ao Ma, Xiongheng Huang, Jingwei Ye, Min Chen, Aoran Zhi, Tao Liu, Ranjha Khan, Asim Ali, Wasim Shah, Aurang Zeb, , Baolu Shi

This study identifies DNAH12 mutations causing male infertility by disrupting DNAH1 and DNALI1 recruitment in sperm flagella, confirmed in human and mouse models.

eLife · Mar 27, 2025Peer-reviewedGenetics

Disrupted Sphingosine-1-Phosphate Homeostasis Drives Nephrotoxicity in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome (SPLIS)

Adam Majcher, Kathrin Buder, Ranjha Khan, Julie Deane Saba, Thorsten Hornemann

This paper investigates SPLIS, showing that S1P accumulation in SPL-deficient cells leads to nephrotoxicity, which can be mitigated by Fasudil.

bioRxiv · Jan 21, 2025 · PreprintPhysiology