Systems BiologybioRxivPreprint
STAT1 -- p53 Dynamics Program Cell Fate through p21 and PUMA
M.K. Francis Didier Tshianyi, Rebecca Walo Omana, Apollinaire Ndondo Mboma…·Didier Gonze
The paper develops a mechanistic model of p53 dynamics regulated by STAT1, showing how different oscillatory patterns predict cell fate outcomes like arrest, senescence, and apoptosis.
DOI 10.1101/2025.10.28.685172