Didier Gonze

The paper develops a mathematical model and formula (HOMA-C) to quantify beta cell carrying capacity in prediabetes, showing significant variation and its association with diabetes risk.

The paper develops a model-based analysis of how p53 stress memory influences JAK/STAT1 antiviral signaling, showing it redistributes STAT1 activity and affects viral control outcomes.

This study identifies temperature-driven diurnal rhythms in CESA8 expression, linking secondary cell wall thickening to stem elongation in grasses.

The paper demonstrates alternative states in a human gut microbial community and identifies phenotype switching as the mechanism driving their emergence.

The paper develops a mechanistic model of p53 dynamics regulated by STAT1, showing how different oscillatory patterns predict cell fate outcomes like arrest, senescence, and apoptosis.

This paper quantifies how ecological memory affects community dynamics by incorporating it into models and shows its impact on resilience, stability, and state shifts.

The paper shows that magnesium deficiency in Arabidopsis seedlings increases circadian period and dampens oscillation amplitude, likely through translational mechanisms.

The paper models how Let-7 couples cell cycle and transformation gene regulatory networks, showing their mutual control and role in cancer progression and tumor heterogeneity.

The paper studies synthetic gut communities to understand species interactions and emergent behavior through culturing, modeling, and transcriptomics.