Chronobot: Deep learning guided time-resolved cryo-EM captures molecular choreography of RecA in homology search
Märt-Erik Mäeots, Simon Tupin, Mohammad M. N. Esfahani, Juan B. Rodríguez‐Molina, Julie A. Clapperton, Aran Amin, Albane Imbert, Radoslav Ivanov Enchev
Chronobot improves cryo-EM sample quality by 11-fold using deep learning for ice thickness quantification, enabling visualization of transient RecA-dsDNA intermediates during homology search.
bioRxiv · Apr 21, 2025 · PreprintBiochemistry