Author

Julie A. Clapperton

The Francis Crick InstituteORCID 0009-0008-9914-7729Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Märt-Erik MäeotsiD· 2 shared Radoslav Ivanov EncheviD· 2 shared Albane ImbertiD· 1 shared Aran Amin· 1 shared Juan B. Rodríguez‐MolinaiD· 1 shared Mohammad M. N. Esfahani· 1 shared Mohammed ShaabaniD· 1 shared Shan Ding· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Märt-Erik MäeotsORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJan 23, 2026

Structural Basis of CSN-mediated SCF Deneddylation

Shan Ding, Julie A. Clapperton, Märt-Erik Mäeots…·Radoslav Ivanov Enchev

This study uses cryo-EM to reveal structural intermediates of CSN-mediated SCF deneddylation, providing insights into the mechanism and potential for drug design.

2 citations

cryo-EMexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintApr 21, 2025

Chronobot: Deep learning guided time-resolved cryo-EM captures molecular choreography of RecA in homology search

Märt-Erik Mäeots, Simon Tupin, Mohammad M. N. Esfahani…·Radoslav Ivanov Enchev

Chronobot improves cryo-EM sample quality by 11-fold using deep learning for ice thickness quantification, enabling visualization of transient RecA-dsDNA intermediates during homology search.

2 citations

cryo-EMdeep learning

𝕏 PostBluesky