Author

Simon Tupin

The Francis Crick InstituteORCID 0000-0003-0982-8210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Adele Jing Ying Lam· 1 shared Albane ImbertiD· 1 shared Aran Amin· 1 shared Benjamin Hansen· 1 shared James E. MooreiD· 1 shared Jennifer FrattoliniD· 1 shared Joseph M. SherwoodiD· 1 shared Juan B. Rodríguez‐MolinaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Adele Jing Ying Lam

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 12, 2026

Fluid shear magnitude, mechanical history and actin-sensitive coupling shape Piezo1 signalling

See Swee Tang, Margaret Gheorghita, Benjamin Hansen…·Periklis Pantazis

This study shows that Piezo1 signaling is influenced by force magnitude, mechanical history, and actin coupling under fluid shear, using a genetically encoded reporter in engineered cells.

DOI 10.64898/2026.10.10.758220

humanelectronic health records

𝕏 PostBluesky

BiochemistrybioRxivPreprintApr 21, 2025

Chronobot: Deep learning guided time-resolved cryo-EM captures molecular choreography of RecA in homology search

Märt-Erik Mäeots, Simon Tupin, Mohammad M. N. Esfahani…·Radoslav Ivanov Enchev

Chronobot improves cryo-EM sample quality by 11-fold using deep learning for ice thickness quantification, enabling visualization of transient RecA-dsDNA intermediates during homology search.

2 citations

cryo-EMdeep learning

𝕏 PostBluesky