Radoslav Ivanov Enchev

This study uses cryo-EM to reveal structural intermediates of CSN-mediated SCF deneddylation, providing insights into the mechanism and potential for drug design.

The paper shows that the ribosome coordinates folding and assembly of a complex protein to enable efficient biogenesis.

This study investigates how GroEL/ES interacts with nascent proteins on ribosomes, showing that GroEL binds and destabilizes substrates, while GroES facilitates partial encapsulation and refolding.

Chronobot improves cryo-EM sample quality by 11-fold using deep learning for ice thickness quantification, enabling visualization of transient RecA-dsDNA intermediates during homology search.