A single-cell and spatial atlas of prostate cancer reveals the combinatorial nature of gene modules underlying lineage plasticity and metastasis
Hanbing Song, Junxiang Xu, Keila Velázquez-Arcelay, Arda Demirci, Brendan Lapointe Raizenne, Sarah C. Hsu, Joshua Choi, Julia H. Pham, Yih-An Chen, Hannah N. W. Weinstein, Isaac Salzman, Margaret Tsui, Jon Akutagawa, Wisdom Adingo, Ezequiel Goldschmidt, , Franklin W. Huang
The paper constructs a single-cell and spatial atlas of prostate cancer to reveal gene modules driving lineage plasticity and metastasis, identifying new biological insights and a transformer-based model for cell-state classification.
bioRxiv · Mar 27, 2026 · PreprintGenomics