Christopher M. Heaphy

The paper constructs a single-cell and spatial atlas of prostate cancer to reveal gene modules driving lineage plasticity and metastasis, identifying new biological insights and a transformer-based model for cell-state classification.

This study identifies distinct malignant cell states and myeloid glutamate signaling in aggressive pancreatic neuroendocrine tumors, linking them to poor clinical outcomes and therapeutic vulnerabilities.

The paper identifies structural variations in TP53 that inactivate TCAB1, a telomerase chaperone, and show these variations are prevalent in ALT-positive osteosarcoma tumors.

This study demonstrates that spatial transcriptomics can be performed on discarded breast biopsy tissue to generate high-quality data for tumor microenvironment analysis.

This study shows that DAXX mutations induce ALT-associated features in prostate cancer cells, but only in CWR22Rv1 cells, not in LAPC-4 cells.