Epstein-Barr Virus Latent Membrane Protein 1 targets cIAP1, cIAP2 and TRAF2 for Proteasomal Degradation to Activate the Non-canonical NF-κB Pathway
Yizhe Sun, Shunji Li, Bidisha Mitra, Ling Zhong, Aretina Zhang, Benjamin E. Gewurz
This study identifies how LMP1's TES1 region activates non-canonical NF-κB signaling by degrading cIAP1, cIAP2, and TRAF2, distinct from CD40.
PLoS Pathogens · Jan 26, 2026Peer-reviewedMicrobiology