Yizhe Sun

A tonsil organoid model reveals Epstein-Barr virus infected germinal center B cell states during primary infection

This study develops an EBV-infected tonsil organoid model to study B cell states and antiviral responses during primary infection, revealing unique transcriptional programs and immune interactions.

The HUSH Complex Dictates EBV-transformed B cell Sensitivity to NK Cell Surveillance Through Repression of NKG2A Ligand γ-Proto-cadherin

The paper identifies the HUSH complex as a regulator of EBV-transformed B cell sensitivity to NK cell surveillance by repressing the NKG2A ligand γ-protocadherin.

A CRISPR-Cas9 screen Reveals STEEP1 as a Key Host Dependency Factor for Epstein-Barr Virus Latent Membrane Protein 1 Trafficking and Signaling

This paper identifies STEEP1 as a host factor critical for LMP1 trafficking and signaling using a CRISPR-Cas9 screen, showing its role in NF-kB and MAP kinase pathway activation.

Epstein-Barr Virus Latent Membrane Protein 1 targets cIAP1, cIAP2 and TRAF2 for Proteasomal Degradation to Activate the Non-canonical NF-κB Pathway

This study identifies how LMP1's TES1 region activates non-canonical NF-κB signaling by degrading cIAP1, cIAP2, and TRAF2, distinct from CD40.

Single-Cell Integration of Chromatin Accessibility and Transcriptomics Reveals Regulatory Networks in Ovarian Tumor-Infiltrating Adaptive NK Cells

This study integrates chromatin accessibility and transcriptomics data from ovarian tumor-infiltrating adaptive NK cells to identify key transcription factors and their regulatory networks.

Insights into the Absence of Lymphoma Despite Fulminant Epstein-Barr Virus Infection in Patients with XIAP Deficiency

This study investigates why XLP-2 patients, with XIAP deficiency, avoid EBV-driven lymphoma despite severe EBV infection, finding that XIAP loss impairs EBV-induced B-cell outgrowth and promotes apoptosis.

Advancing Adoptive Cell Therapy: Optimized Expansion of Adaptive NK Cells for Solid Tumors

This study shows that IL-21 enhances aNK cell expansion and cytotoxicity against tumors, with tumor lysate boosting their efficacy, validated in a zebrafish model.