A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype
Sara Söderqvist, Annika Viljamaa, Natalie Geyer, Carina Strell, Neda Hekmati, Jennie Engstrand, Ernesto Sparrelid, Caroline Salmén, Rainer L. Heuchel, Argyro Zacharouli, Poya Ghorbani, Sara Harrizi, Yousra Hamidi, Olga Khorosjutina, Stefina Milanova, , Marco Gerling
This study identifies a distinctive PDAC niche in pancreatic lobules characterized by nascent stroma and classical tumor cell phenotype, highlighting the role of acinar-to-ductal metaplasia and microenvironmental factors in tumor progression.
bioRxiv · Mar 14, 2024 · PreprintCancer Biology