Progressive matrix stiffening of tyramine-modified silk fibroin hydrogels governs stage-specific pulmonary fibroblast activation
Mariah Lynn Arral, Maria G. Savvidou, Adam S. Mullis, Aria Z. Yang, Thomas Falcucci, Julie Leonard‐Duke, Pamela L. Graney, Sabrina Madiedo-Podvršan, Sanjana Gopalakrishnan, Jugal Kishore Sahoo, Jing-Jie Huang, Gordana Vunjak‐Novakovic, David Lee Kaplan
This study uses stiffening hydrogels to model fibrosis stages and shows how different stiffness levels affect fibroblast activation and cytokine secretion.
bioRxiv · Jun 4, 2026 · PreprintBioengineering