Author

Mariah Lynn Arral

Carnegie Mellon UniversityORCID 0000-0002-3248-4068Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

David Lee KaplaniD· 2 shared Jugal Kishore SahooiD· 2 shared Kathryn A. WhiteheadiD· 2 shared Sanjana GopalakrishnaniD· 2 shared Adam S. MullisiD· 1 shared Aleksa MilosavljeviciD· 1 shared Alison LuiiD· 1 shared Andrew TsourkasiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBioengineering

David Lee KaplanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular Engineering of Silk via Fatty Acid Esterification for Water-Stable, Anti-fouling, Biocompatible, Implantable Materials

Sanjana Gopalakrishnan, Emilee Zhang, Mariah Lynn Arral, Edward Gordon, Sophie M Steedly, Jugal Kishore Sahoo, Chunmei Li, David Lee Kaplan

This study modifies silk fibroin with fatty acid esterification to create water-stable, anti-fouling, biocompatible materials for implantable applications.

bioRxiv · Oct 21, 2026 · PreprintBioengineering

Progressive matrix stiffening of tyramine-modified silk fibroin hydrogels governs stage-specific pulmonary fibroblast activation

Mariah Lynn Arral, Maria G. Savvidou, Adam S. Mullis, Aria Z. Yang, Thomas Falcucci, Julie Leonard‐Duke, Pamela L. Graney, Sabrina Madiedo-Podvršan, Sanjana Gopalakrishnan, Jugal Kishore Sahoo, Jing-Jie Huang, Gordana Vunjak‐Novakovic, David Lee Kaplan

This study uses stiffening hydrogels to model fibrosis stages and shows how different stiffness levels affect fibroblast activation and cytokine secretion.

bioRxiv · Jun 4, 2026 · PreprintBioengineering

Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo

Elizabeth Voke, Mariah Lynn Arral, Henry John Squire, Teng-Jui Lin, Lining Zheng, Roxana Coreas, Alison Lui, Anthony T. Iavarone, Rebecca L. Pinals, Kathryn A. Whitehead, Markita Patricia Landry

A 16-hour continuous iodixanol density gradient workflow isolates lipid nanoparticle protein coronas from human plasma and shows that vitronectin and C-reactive protein coronas impair mRNA delivery in liver cells.

Nature Communications · Sep 30, 2025Peer-reviewedBioengineering✦ In-depth digest

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

Serena Omo‐Lamai, Yufei Wang, Manthan N. Patel, Aleksa Milosavljevic, Daniel W. Zuschlag, Subhajit Poddar, Jichuan Wu, Liuqian Wang, Fengyi Dong, Carolann L. Espy, Aparajeeta Majumder, Eno‐Obong Essien, Mengwen Shen, Breana Channer, Tyler Ellis Papp, , Jacob Samuel Brenner

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

Nature Nanotechnology · Aug 11, 2025Peer-reviewedBioengineering