Mutation in Wdr45 leads to early motor dysfunction and widespread aberrant axon terminals in a beta-propeller protein associated neurodegeneration (BPAN) patient-inspired mouse model
Brandon L. Meyerink, Krishna S. Karia, Mitchell J. Rechtzigel, Prithvi R. Patthi, Ariana C. Edwards, Jessica M. Howard, Elizabeth R. Aaseng, Saboor Aftab, Jill M. Weimer, Louis‐Jan Pilaz
This study creates a BPAN patient-inspired mouse model with a Wdr45 mutation, revealing motor dysfunction, axon terminal abnormalities, and disrupted pathways in the brain.
Frontiers in Neuroscience · Feb 28, 2025Peer-reviewedNeuroscience