NeuroscienceFrontiers in NeurosciencePeer-reviewed
Mutation in Wdr45 leads to early motor dysfunction and widespread aberrant axon terminals in a beta-propeller protein associated neurodegeneration (BPAN) patient-inspired mouse model
Brandon L. Meyerink, Krishna S. Karia, Mitchell J. Rechtzigel…·Louis‐Jan Pilaz
This study creates a BPAN patient-inspired mouse model with a Wdr45 mutation, revealing motor dysfunction, axon terminal abnormalities, and disrupted pathways in the brain.