Structural and functional landscape of α-synuclein fibril conformations amplified from cerebrospinal fluid
Arpine Sokratian, Ye Zhou, Enquan Xu, Elizabeth G. Viverette, Lucas B. Dillard, Yuan Yuan, Joshua Y. Li, Ariana Matarangas, Jonathan Bouvette, Mario Juan Borgnia, Alberto Bartesaghi, Andrew B. West
The paper identifies six novel α-synuclein fibril assemblies from cerebrospinal fluid samples and shows they have distinct functional properties despite no single structural feature predicting their function.
bioRxiv · Jul 13, 2022 · PreprintNeuroscience