Pseudo-spectral angle mapping for automated pixel-level analysis of highly multiplexed tissue image data
Madeleine S. Durkee, Junting Ai, Gabriel Casella, Thao Cao, Anthony Chang, Ariel Halper-Stromberg, Bana Jabrì, Marcus R. Clark, Maryellen Lissak Giger
This paper introduces pSAM, a method for analyzing high-plex immunofluorescence images, and shows it can generalize across different staining panels and tissues without manual annotation.
bioRxiv · Jan 9, 2024 · PreprintBioinformatics