Marcus R. Clark

This study shows BRWD1 is essential for maintaining epigenetic states in germinal center B cells, affecting their function and subset identity.

The paper identifies spatially distinct macrophage-fibroblast interactions in lupus nephritis that drive myofibroblast heterogeneity and fibrosis.

This paper introduces Sprox-seq, a multi-omic technique that maps protein interactions and mRNA in human germinal centers, revealing distinct B cell maturation pathways and spatially-enriched immune regulatory complexes.

This study shows that autoreactive B cells in rejecting kidney allografts produce pathogenic IgG independently of donor-specific antibodies, highlighting a novel mechanism in antibody-mediated rejection.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze myeloid cell dynamics in lupus nephritis, showing shifts in immune responses linked to disease progression.

The paper uses high-dimensional spatial proteomics and a machine learning pipeline to identify and quantify disease-specific renal damage states in lupus nephritis and renal allograft rejection.

The paper quantifies immune cell populations in lupus nephritis and renal allograft rejection using microscopy and computational tools, identifying distinct inflammatory trajectories.

This study shows that GAGA motifs 5' to Jk RSSs are essential for nucleosome positioning and Vk-Jk recombination in mice.

This paper introduces pSAM, a method for analyzing high-plex immunofluorescence images, and shows it can generalize across different staining panels and tissues without manual annotation.