Junting Ai

Spatially Distinct Macrophage Subsets Drive Myofibroblast Heterogeneity and Maladaptive Fibrosis in Lupus Nephritis

The paper identifies spatially distinct macrophage-fibroblast interactions in lupus nephritis that drive myofibroblast heterogeneity and fibrosis.

Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze myeloid cell dynamics in lupus nephritis, showing shifts in immune responses linked to disease progression.

High-dimensional spatial proteomics and novel machine learning pipeline identifies disease specific renal damage states

The paper uses high-dimensional spatial proteomics and a machine learning pipeline to identify and quantify disease-specific renal damage states in lupus nephritis and renal allograft rejection.

Resolution of in situ inflammation in human lupus nephritis into principal immune cell trajectories

The paper quantifies immune cell populations in lupus nephritis and renal allograft rejection using microscopy and computational tools, identifying distinct inflammatory trajectories.

Pseudo-spectral angle mapping for automated pixel-level analysis of highly multiplexed tissue image data

This paper introduces pSAM, a method for analyzing high-plex immunofluorescence images, and shows it can generalize across different staining panels and tissues without manual annotation.